BPC-157 and TB-500 work in concert to repair tissues on multiple fronts. Both peptides promote angiogenesis, the formation of new blood vessels. This is critical for delivering nutrients and oxygen to injured areas. BPC-157, as described earlier, also upregulates various growth factors (like EGF, VEGF) and directly facilitates cell migration and collagen synthesis at injury sites, particularly in tendons and gut tissue. TB-500 (Thymosin Beta-4 fragment) has a somewhat broader systemic effect: it binds to actin in cells, modulating cell skeleton dynamics and enabling cells to move and build new tissue more effectively. It also decreases inflammation and fibrosis. TB-500 is known to travel long distances in the body (due to its small size and ability to circulate), spreading healing influence even to remote areas. Together, when BPC-157 and TB-500 are administered, angiogenesis is markedly increased (more than either alone), and the combination often results in more robust tissue regeneration (athletes report faster healing than expected for severe injuries). This blend can encourage the organization of collagen fibers in healing tissue to be more functional and less scar-like. Moreover, BPC-157 protects and heals the gut and can modulate neurotransmitters, while TB-500 has been noted to help with central nervous system injuries (like reducing scar formation in spinal cord injuries). In essence, the blend triggers the body’s healing cascade at both a local and systemic level: new blood vessels form, inflammation subsides, and cells responsible for repair (fibroblasts, myocytes, osteoblasts, etc.) are activated to rebuild damaged structures.