MOTS-C (Mitochondrial ORF of the Twelve S rRNA type-C) helps the body adapt to metabolic stress at a cellular level. It activates the AMPK pathway – essentially tricking cells into a “high-energy demand” state similar to exercise. By doing so, MOTS-C shifts the body’s fuel preference from carbohydrates to fats, especially under conditions like exercise or fasting. This leads to increased glucose uptake in muscles and enhanced fatty acid oxidation. The peptide also upregulates genes associated with metabolism and longevity (such as PGC-1α and SIRT1), improves insulin sensitivity, and enhances mitochondrial function. Users often report a noticeable increase in natural energy and endurance for days following a dose, as the peptide confers many benefits akin to consistent exercise – from better blood sugar control to improved muscle performance. Additionally, by activating cellular stress response pathways, MOTS-C exhibits protective effects against age-related metabolic decline and supports cognitive function.