Name: Methylene Blue
SKU: ERL-METHYLENEBLUE
Availability: InStock

Methylene Blue

A century-old compound with medical and research uses, Methylene Blue (MB) has recently gained attention as a nootropic and metabolic enhancer. At low doses, it can improve mitochondrial function, increase mental clarity, and act as a neuroprotective and anti-aging agent. It also has a history as a dye and antiparasitic, and at higher doses is used to treat conditions like methemoglobinemia.

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Benefits
Increases serotonin levels in the brain, which can uplift mood and reduce anxiety (acts as a mild MAO-A inhibitor at low doses)
Sharpens cognitive function and reduces “brain fog” – users report improved memory, clarity, and processing speed
Boosts cellular energy production by improving mitochondrial efficiency (enhances the electron transport chain in cells)
Exhibits neuroprotective properties (being studied in Alzheimer’s and Parkinson’s for its potential to protect neurons and improve mitochondrial function)
Provides anti-aging benefits: as an antioxidant, it reduces oxidative stress and can improve skin appearance (reduces fine wrinkles, often used in skincare research)
Has broad anti-microbial effects (was originally used as an anti-malarial and still used for certain parasitic or bacterial infections)
Reduces inflammation throughout the body by lowering reactive oxygen species and supporting healthy cellular metabolism
Dosage & Usage
For cognitive and anti-aging purposes, a typical low dose is 10–20 mg per day. The product here is a sublingual solution of 25 mg/mL. Start with 0.5 mL (12.5 mg) under the tongue once per day. Hold the solution under the tongue for about 60 seconds to allow absorption, then swallow. After 1–2 weeks, if desired, you can increase to 1 mL (25 mg) per day. It’s best taken in the morning or early afternoon, as some people find it mildly stimulating or focusing. Avoid taking it late at night as it could interfere with sleep in sensitive individuals. Note: Methylene Blue will stain – the solution is a deep blue color, and it can temporarily discolor the mouth or urine a green-blue hue (this is normal). To minimize mouth staining, you can mix it in a small amount of water and drink it, but sublingual has better bioavailability. Use a straw or dropper carefully to avoid staining teeth or countertops (any blue stains on skin or surfaces can be cleaned with vitamin C solution, which decolorizes it).
Mechanism of Action
At the cellular level, Methylene Blue (MB) accepts and donates electrons within the mitochondria. It can shuttle electrons in the electron transport chain between complexes I–IV, essentially bypassing any bottlenecks. By doing this, MB ensures that mitochondria can keep producing ATP (cellular energy) efficiently, even under stress or when certain pathways are impaired. This is why MB is seen as a powerful metabolic enhancer – it improves mitochondrial respiration, resulting in increased energy availability for the cell. In the brain, MB’s actions lead to better energy supply for neurons and a reduction in damaging reactive oxygen species. MB is also a reversible MAO-A inhibitor at low doses, which means it prevents the breakdown of neurotransmitters like serotonin. This is why low-dose MB can elevate mood and have an antidepressant-like effect. However, it’s a gentle effect compared to pharmaceutical MAOIs. Additionally, MB has antioxidant properties – it can neutralize nitric oxide (NO) and reduce oxidative stress in cells. By reducing NO, it prevents the overproduction of the harmful free radical peroxynitrite (implicated in neurodegeneration). It also protects mitochondrial DNA and can even upregulate certain protective pathways in cells. On the skin, MB’s antioxidant and electron-shuttling abilities help fibroblasts (collagen-producing cells) function better, which is why it has shown promise in improving skin elasticity and reducing fine lines when applied topically. As an antiparasitic (at much higher doses than nootropic use), MB interferes with the parasite’s metabolism (used historically for malaria). In summary, MB enhances mitochondrial function, modulates neurotransmitters, and protects cells from oxidative damage, which collectively explain its nootropic, anti-anxiety, and anti-aging effects.
Volume
Notes
Caution – interaction with SSRIs: Because MB at higher doses can inhibit MAO-A, do not combine with SSRI antidepressants or certain other psychiatric medications, as this could lead to serotonin syndrome. Low-dose MB (<= methylene blue 2 mg/kg IV equivalent) is generally considered safe, but always consult guidance if on serotonergic drugs. Also, MB will turn urine blue-green; this is normal. If you get a deep blue staining on the tongue or teeth, it will fade; brushing teeth or using vitamin C mouthwash can help. Keep doses low – high doses of MB (above nootropic range) are not more effective for these purposes and can actually act as a pro-oxidant. Most find a sweet spot around 10–20 mg daily. Discontinue use 48 hours before any surgery that uses pulse oximetry or certain diagnostic tests, as MB can interfere with readings (it mildly tints blood). If using topically in skincare, note it will stain the skin blue temporarily (usually absorbed or washed off). Finally, always measure doses carefully; a little goes a long way with MB.
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